Phenotypes Associated with This Genotype

Genotype
MGI:3607778

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Tg(KRT5-cre)1Xya/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased stomach tumor incidence ( J:101602 )

• some die of stomach carcinomas by 3 months of age

mortality/aging

premature death ( J:101602 )

• some die by 3 months of age due to stomach carcinomas

neoplasm

increased stomach tumor incidence ( J:101602 )

• some die of stomach carcinomas by 3 months of age

increased skin tumor incidence ( J:101602 )

• tumor formation is accelerated in comparison to conditional keratinocyte targeted Smad4^tm2.1Cxd or Pten^tm2Mak mutant mice

increased skin papilloma incidence ( J:101602 )

• develop visible squamous papillomas on their backs at 2 months of age

increased carcinoma incidence ( J:101602 )

• some die of stomach carcinomas by 3 months of age

decreased tumor latency ( J:101602 )

• tumor formation is accelerated in comparison to conditional keratinocyte targeted Smad4^tm2.1Cxd or Pten^tm2Mak mutant mice

integument

increased keratinocyte proliferation ( J:101602 )

• exhibit persistently proliferating follicular keratinocytes

epithelioid cyst ( J:101602 )

• exhibit enlarged cysts surrounded by a multilayered epithelium filled with keratinized debris or pigments

alopecia ( J:101602 )

• exhibit obvious hair loss 2 months after birth, about 1 month earlier than conditional keratinocyte targeted Smad4^tm2.1Cxd mutant mice

thick hair follicle outer root sheath ( J:101602 )

• outer root sheath is thicker at P18

abnormal hair follicle regression ( J:101602 )

• hair follicles fail to go into catagen stage, indicating blocked regression

increased hair follicle cell proliferation ( J:101602 )

• hair follicles have significantly more proliferating cells at P18 than conditional keratinocyte targeted Pten^tm2Mak mutant mice

thick epidermis ( J:101602 )

• thickened epidermis is observed at P18

increased skin tumor incidence ( J:101602 )

• tumor formation is accelerated in comparison to conditional keratinocyte targeted Smad4^tm2.1Cxd or Pten^tm2Mak mutant mice

increased skin papilloma incidence ( J:101602 )

• develop visible squamous papillomas on their backs at 2 months of age

cellular

increased keratinocyte proliferation ( J:101602 )

• exhibit persistently proliferating follicular keratinocytes

growth/size/body

epithelioid cyst ( J:101602 )

• exhibit enlarged cysts surrounded by a multilayered epithelium filled with keratinized debris or pigments