Phenotypes for Bace1 Bace2 MGI:3607595 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bace1^tm1Psa/Bace1^tm1Psa Bace2^tm1Bdes/Bace2^tm1Bdes
Genetic Background	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1^tm1Psa mutation (0 available); any Bace1 mutation (27 available)
Bace2^tm1Bdes mutation (2 available); any Bace2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:100925 )

• approximately 42% die within the first 3-5 days after birth and an additional 20% die within the first 3-4 weeks of age

growth/size/body

decreased body size ( J:100925 )

• mice surviving to adulthood are smaller than controls

cachexia ( J:100925 )

• the 20% that die by 3-4 weeks of age die from a wasting syndrome

nervous system

abnormal nervous system physiology ( J:100925 )

• neurons and glia do not process APP and thus do not produce Abeta

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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