Phenotypes Associated with This Genotype

Genotype
MGI:3606694

• Allelic Composition: Tg(DO11.10)10Dlo/?
• Genetic Background: involves: BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus physiology ( J:70572 )

• 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes

• apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas

• 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla

• peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8

decreased double-positive T cell number ( J:70572 )

• CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide

decreased CD4-positive, alpha-beta T cell number ( J:70572 )

• CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide

hematopoietic system

abnormal thymus physiology ( J:70572 )

• 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes

• apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas

• 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla

• peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8

decreased double-positive T cell number ( J:70572 )

• CD4+CD8+TCR cells in thymic cortex are reduced by 55% after administration of OVA 323-339 peptide

decreased CD4-positive, alpha-beta T cell number ( J:70572 )

• CD4+ CD8- TCR thymocytes are reduced in absolute numbers after administration of OVA 323-339 peptide

endocrine/exocrine glands

abnormal thymus physiology ( J:70572 )

• 20 hours after administration of OVA323-339 peptide, apoptosis, DNA degradation, chromatin condensation, and cell shrinkage occur in the majority of cortical thymocytes

• apoptosis occurs throughout the thymus including the subcapsular and deep cortical areas

• 3 days after administration of peptide the cortical thymus is acellular; however, normal cellularity exists in the medulla

• peptide administration does not effect small number of thymocytes that express only the beta chain transgene Vb8