Phenotypes Associated with This Genotype

Genotype
MGI:3606634

• Allelic Composition: Sele^tm2Alb/Sele^tm2Alb; Selp^tm1Bay/Selp^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte cell number ( J:101979 )

• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection

• decreased peritoneal WBC count relative to peripheral WBC count following infection

increased neutrophil cell number ( J:101979 )

• neutrophilia in contrast to controls following infection with S. pneumoniae

• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection

eye inflammation ( J:101979 )

• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

increased susceptibility to bacterial infection ( J:101979 )

• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae

• decreased survival rate after post-infection day 5

• decreased ability to clear bacteremia among survivors

behavior/neurological

abnormal pilomotor reflex ( J:101979 )

• observed following infection with S. pneumoniae

tremors ( J:101979 )

• observed following infection with S. pneumoniae

head tilt ( J:101979 )

• observed following infection with S. pneumoniae

decreased locomotor activity ( J:101979 )

• observed following infection with S. pneumoniae

spinning ( J:101979 )

• observed following infection with S. pneumoniae

growth/size/body

weight loss ( J:101979 )

• 48 hours post-infection with S. pneumoniae

vision/eye

eye inflammation ( J:101979 )

• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system

abnormal leukocyte cell number ( J:101979 )

• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection

• decreased peritoneal WBC count relative to peripheral WBC count following infection

increased neutrophil cell number ( J:101979 )

• neutrophilia in contrast to controls following infection with S. pneumoniae

• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection