Analysis Tools
renal/urinary system
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• unspecified kidney lesions related to genotype were present in homozygous mice
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• 49 day homozygous females, 300 day homozygous males
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• weight increased, 49 day homozygous female and males
• weight to body weight ratio increased, 49 day homozygous female and male, and 300 day homozygous female and male
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• moderate to severe bilateral renal pelvic dilation was present at 49 days in two homozygous females and a homozygous male, and at 300 days in two homozygous males
• minimal or moderate unilateral renal pelvic dilation was present at 300 days in homozygous females
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behavior/neurological
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• homozygotes required a lower dose of metrazol to induce tonic/clonic seizure and death in the metrazol test
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nervous system
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• homozygotes required a lower dose of metrazol to induce tonic/clonic seizure and death in the metrazol test
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growth/size/body
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• 49 day homozygous females, 300 day homozygous males
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• weight increased, 49 day homozygous female and males
• weight to body weight ratio increased, 49 day homozygous female and male, and 300 day homozygous female and male
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