Analysis Tools
mortality/aging
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• mutants die shortly after birth
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renal/urinary system
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• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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• no glomeruli are present at any stage of kidney development
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• at E14.5 mutant kidneys show only condensation and renal vesicle formation and not tubulogenesis or glomerulogenesis that are seen in wild-type mice
• at E16.5 evidence of cap formation is mostly missing and few vesicles remain in the mutant kidneys and those remaining vesicles do not show signs of tubulogenesis
• at E18.5 the hypocellular kidney is largely devoid of nephron epithelia
• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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• at E18.5 the few remaining ureteric bud radii fail to bifurcate in the cortical nephrogenic region; however, somite formation, tendon progenitor populations fro E10.5 - E14.5, and limb bud induction are normal
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• at E14.5 ureteric bud branching is dramatically reduced
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limbs/digits/tail
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• most mutants lack at least one hindlimb digit; however, limb bud induction is normal
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skeleton
| N |
• no defects are seen in skeletal development including rib formation
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cellular
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• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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