Phenotypes Associated with This Genotype

Genotype
MGI:3606115

• Allelic Composition: Tg(APPSWE)2123Kha/0
• Genetic Background: FVB/N-Tg(APPSWE)2123Kha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29880 )

• 50% dead at 75 days of age

nervous system

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex

behavior/neurological

decreased exploration in new environment ( J:29880 )

• 40% of mice are neophobic at 100 days of age; transient cessations of exploratory behavior in a novel environment are observed

reproductive system

reduced fertility ( J:29880 )

• mice are poor breeders