Analysis Tools
hematopoietic system
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• double homozygotes exhibit no major histologic abnormalities in the lymph nodes and spleen or signs of severe plasmacytosis in the lymph nodes
• although B cell development is delayed, neither spleen hyperplasia nor abnormal expansion of the lymphoid or myeloid compartments is observed, suggesting that Il6 inactivation prevents the pathological development of Castleman's disease observed in Cebpbtm1Vpo mice
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