Phenotypes Associated with This Genotype

Genotype
MGI:3605876

• Allelic Composition: Sfn^Er/Sfn⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:6200 )

• increased mortality starting at about the time hair loss starts and continuing through weaning and a little after

• mice surviving the post weaning period are fertile and live normal lifespans

growth/size/body

postnatal growth retardation ( J:6200 )

• starting about the same time as hair loss

neoplasm

increased skin papilloma incidence ( J:12025 )

• 67% frequency in mice older than 6 months

• begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns

• no evidence of virus particles

increased squamous cell carcinoma incidence ( J:12025 )

• 67% frequency in mice older than 6 months

• squamous cell carcinomas in the fleshy base of large cutaneous horns

• no evidence of virus particles

integument

premature hair loss ( J:6200 , J:29020 )

• first coat lost by 3 weeks then quickly replaced and lost again (J:6200)

• hair loss begins around eyes and nose (J:6200)

• normal until around 13 days when hair loss begins (J:29020)

sparse hair ( J:29020 )

increased skin papilloma incidence ( J:12025 )

• 67% frequency in mice older than 6 months

• begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns

• no evidence of virus particles