Phenotypes Associated with This Genotype

Genotype
MGI:3605829

• Allelic Composition: Cebpb^tm1Vpo/Cebpb⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland duct morphology ( J:48513 )

♀ • at maturity (8-12 weeks), ~20% of virgin female heterozygotes exhibit significantly enlarged, cystic ducts with bloated terminal end buds

♀ • ductal enlargement is NOT due to accumulation of proteinaceous material in the ducts or hyperplasia of the ductal epithelium

♀ • transplantation of heterozygous mammary epithelium into cleared mammary fat pads of nude mice results in an intermediate phenotype consisting of both normal and bloated ducts

integument

abnormal mammary gland duct morphology ( J:48513 )

♀ • at maturity (8-12 weeks), ~20% of virgin female heterozygotes exhibit significantly enlarged, cystic ducts with bloated terminal end buds

♀ • ductal enlargement is NOT due to accumulation of proteinaceous material in the ducts or hyperplasia of the ductal epithelium

♀ • transplantation of heterozygous mammary epithelium into cleared mammary fat pads of nude mice results in an intermediate phenotype consisting of both normal and bloated ducts