About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3605230
Allelic
Composition
Largemyd/Largemyd
Genetic
Background
B6.Cg-Largemyd/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Largemyd mutation (3 available); any Large mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• almost 50% thinner than in controls (J:100214)
• almost 50% thinner than in controls (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• mitochondria are swollen with severe disruption of cristae (J:100214)
• exhibits extracelluelar edema (J:100214)
• layer is thinner than in control littermates (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• mitochondria are swollen with severe disruption of cristae (J:100214)
• exhibits extracelluelar edema (J:100214)
• layer is thinner than in control littermates (J:100214)
• amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice (J:100214)
• larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice (J:100214)
• maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice (J:100214)
• amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice (J:100214)
• larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice (J:100214)
• maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice (J:100214)

muscle
• adult onset (J:100214)
• adult onset (J:100214)
• exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age (J:100214)
• by 4 months diaphragm exhibits necrosis and fatty infiltration (J:100214)
• exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age (J:100214)
• by 4 months diaphragm exhibits necrosis and fatty infiltration (J:100214)
• occasional signs of fiber-type grouping in 6 month old mice (J:100214)
• occasional signs of fiber-type grouping in 6 month old mice (J:100214)

cardiovascular system
• myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice (J:100214)
• lesions observed in the left and right atria and ventricles (J:100214)
• myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice (J:100214)
• lesions observed in the left and right atria and ventricles (J:100214)
• adult onset (J:100214)
• adult onset (J:100214)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory