About   Help   FAQ
Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Large1myd mutation (3 available); any Large1 mutation (107 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• almost 50% thinner than in controls
• layer is disorganized with a reduction in synaptic complexes
• mitochondria are swollen with severe disruption of cristae
• exhibits extracelluelar edema
• layer is thinner than in control littermates
• amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice
• larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice
• maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice

• adult onset
• exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age
• by 4 months diaphragm exhibits necrosis and fatty infiltration
• occasional signs of fiber-type grouping in 6 month old mice

cardiovascular system
• myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice
• lesions observed in the left and right atria and ventricles
• adult onset

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory