Phenotypes Associated with This Genotype

Genotype
MGI:3604385

• Allelic Composition: Wnt3a^tm1Amc/Wnt3a^vt
• Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:31335 )

• only about 50% of compound heterozygotes live longer than 4 weeks compared to 90% of Wnt3a^vt heterozygotes

limbs/digits/tail

absent tail ( J:31335 )

skeleton

abnormal thoracic vertebrae morphology ( J:31335 )

• deformities seen as far anterior as the 7th thoracic vertebra

decreased thoracic vertebrae number ( J:31335 )

• the most severely affected mutants have a reduction in the number of thoracic vertebrae

decreased lumbar vertebrae number ( J:31335 )

• none of the compound heterozygotes have all of the lumbar vertebrae

absent sacral vertebrae ( J:31335 )

• no normal sacral vertebrae are seen

embryo

decreased embryo size ( J:31335 )

• the most severely affected mutants are smaller than wild-type littermates

spina bifida ( J:31335 )

• the most severely affected mutants display spina bifida of the posterior neural tube

abnormal somite development ( J:31335 )

• somites do not extend as far caudally as in wild-type embryos and malformed somites are seen rostral to the last somite

nervous system

spina bifida ( J:31335 )

• the most severely affected mutants display spina bifida of the posterior neural tube

behavior/neurological

hindlimb paralysis ( J:31335 )

• the most severely affected mutants display hindlimb paralysis

growth/size/body

decreased embryo size ( J:31335 )

• the most severely affected mutants are smaller than wild-type littermates

renal/urinary system

abnormal urination ( J:31335 )

• in several cases severely affected mutants displayed accumulation of urine in the kidneys and ureters

digestive/alimentary system

abnormal intestine morphology ( J:31335 )

• in several cases severely affected mutants displayed hyperextended intestines