Phenotypes Associated with This Genotype

Genotype
MGI:3603663

• Allelic Composition: Men1^tm1.2Ctre/Men1^tm1.2Ctre; Tg(Ins2-cre)1Dh/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:85042 )

• abnormally large islets with pleomorphic cells of variable size and shape are seen at 20 weeks of age

increased insulinoma incidence ( J:85042 )

• 6 of 33 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes

• a mild sex bias is seen with 3 of 12 virgin females developing adenomas compared to 3 of 21 males

• adenomas are detected by 44 weeks of age

homeostasis/metabolism

decreased circulating glucose level ( J:85042 )

• fasting blood glucose levels are decreased

increased circulating insulin level ( J:85042 )

• fasting serum insulin levels are increased

neoplasm

increased insulinoma incidence ( J:85042 )

• 6 of 33 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes

• a mild sex bias is seen with 3 of 12 virgin females developing adenomas compared to 3 of 21 males

• adenomas are detected by 44 weeks of age