endocrine/exocrine glands
• abnormally large islets with pleomorphic cells of variable size and shape are seen at 20 weeks of age
• in 60 week old mutants islet volume has increased 7-fold
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• adenomas are detected by 30 weeks of age
• 3 of 26 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a mild sex bias is seen with 2 of 13 virgin females developing adenomas compared to 1 of 13 males
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homeostasis/metabolism
• fasting blood glucose levels are decreased
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• fasting serum insulin levels are increased
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neoplasm
• adenomas are detected by 30 weeks of age
• 3 of 26 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a mild sex bias is seen with 2 of 13 virgin females developing adenomas compared to 1 of 13 males
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