Mouse Genome Informatics
cn
    Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Alb-cre)21Mgn/0

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• secrete 70% less insulin in response to glucose stimulus
• 10% increase in fed blood glucose concentration
• post-absorptive (fed) plasma insulin concentrations twice that of controls
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced
• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies
• mild insulin resistance

endocrine/exocrine glands
• secrete 70% less insulin in response to glucose stimulus

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826