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Phenotypes Associated with This Genotype
Genotype
MGI:3603013
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (36 available)
Tg(Alb-cre)21Mgn mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• secrete 70% less insulin in response to glucose stimulus
• 10% increase in fed blood glucose concentration
• post-absorptive (fed) plasma insulin concentrations twice that of controls
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced
• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies
• mild insulin resistance

endocrine/exocrine glands
• secrete 70% less insulin in response to glucose stimulus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:51826


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory