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Phenotypes Associated with This Genotype
Genotype
MGI:3590487
Allelic
Composition
Itgb2tm1Bay/Itgb2tm2Bay
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (9 available)
Itgb2tm2Bay mutation (3 available); any Itgb2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: mild, predominantly lymphocytic inflammatory cell response located primarily in the superficial dermis and the basal layer of the epidermis

integument
• Background Sensitivity: mild, predominantly lymphocytic inflammatory cell response located primarily in the superficial dermis and the basal layer of the epidermis
• Background Sensitivity: compound heterozygous mice develop chronic inflammatory skin disease on the mixed PL/J, 129S7/SvEvBrd, and C57BL/6J background but not on a C57BL/6J background
• 40% of (PL/J X C57BL/6J)F1 compound heterozygotes develop mild psoriasifrom dermatitis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
psoriasis DOID:8893 OMIM:PS177900
J:84126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory