Phenotypes Associated with This Genotype

Genotype
MGI:3590487

• Allelic Composition: Itgb2^tm1Bay/Itgb2^tm2Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

dermatitis ( J:84126 )

• Background Sensitivity: mild, predominantly lymphocytic inflammatory cell response located primarily in the superficial dermis and the basal layer of the epidermis

integument

dermatitis ( J:84126 )

• Background Sensitivity: mild, predominantly lymphocytic inflammatory cell response located primarily in the superficial dermis and the basal layer of the epidermis

hyperkeratosis ( J:84126 )

acanthosis ( J:84126 )

abnormal skin condition ( J:84126 )

• Background Sensitivity: compound heterozygous mice develop chronic inflammatory skin disease on the mixed PL/J, 129S7/SvEvBrd, and C57BL/6J background but not on a C57BL/6J background

psoriasis ( J:84126 )

• 40% of (PL/J X C57BL/6J)F1 compound heterozygotes develop mild psoriasifrom dermatitis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:84126