Phenotypes Associated with This Genotype

Genotype
MGI:3590220

• Allelic Composition: Caml^tm1Rjb/Caml^tm2Rjb; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different

decreased single-positive T cell number ( J:100536 )

• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control

• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells

• in 8-9 weeks old mutant mice, T cell numbers were more similar

immune system

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different

decreased single-positive T cell number ( J:100536 )

• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control

• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells

• in 8-9 weeks old mutant mice, T cell numbers were more similar

cellular

increased T cell apoptosis ( J:100536 )

• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

endocrine/exocrine glands

decreased thymocyte number ( J:100536 )

• the average numbers of total thymocytes were reduced by half

• the number of cells at the double-negative stage was not different