Phenotypes Associated with This Genotype

Genotype
MGI:3590189

• Allelic Composition: Cdkn1a^tm1Led/Cdkn1a^tm1Led; Hus1^tm1Led/Hus1^tm1Led
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to hydroxyurea induced cell death ( J:63869 )

• double homozygous MEFs are 5- to 10-fold more sensitive to hydroxyurea compared to cells null for Cdkn1a only

increased cellular sensitivity to ultraviolet irradiation induced cell death ( J:63869 )

• double homozygous MEFs are more sensitive to UV but not to ionizing radiation compared to cells null for Cdkn1a only

chromosome breakage ( J:63869 )

• mutant MEFs display increased numbers of chromosomal abnormalities; however unlike MEFs from Hus1 single homozygotes cells from 3 of 13 double homozygotes proliferated in culture