Phenotypes Associated with This Genotype

Genotype
MGI:3589871

• Allelic Composition: Dicer1^tm1Bdh/Dicer1^tm1Bdh; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

forelimb oligodactyly ( J:100475 )

• forelimbs show loss of digits and some fusion of digits

abnormal forelimb morphology ( J:100475 )

• at E11 the forelimbs are smaller and at E12.5 the forelimb size resembles that of wild-type forelimbs at E11.5

• starting at E10.5 increased cell death is seen in the limb mesoderm

abnormal hindlimb morphology ( J:100475 )

• the hindlimbs are smaller but not as severely affected as the forelimbs

• starting at E12.5 increased cell death is seen in the limb mesoderm

skeleton

abnormal long bone morphology ( J:100475 )

• the long bones of the arms and legs appear twisted

delayed endochondral bone ossification ( J:100475 )

• bone formation from cartilage is delayed in the long bones of the limbs