Phenotypes Associated with This Genotype

Genotype
MGI:3589755

• Allelic Composition: Pafah1b1^tm1Awb/Pafah1b1⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disruption of hippocampal layers in Lrp8^tm1Her/Lrp8^tm1Her, Pafah1b1^tm1Awb/Pafah1b1⁺, and Lrp8^tm1Her/Lrp8^tm1Her Pafah1b1^tm1Awb/Pafah1b1⁺ mice

nervous system

increased neuron apoptosis ( J:100552 )

• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone

abnormal neuronal migration ( J:100552 )

• migration defects in the hippocampus are seen

abnormal hippocampus pyramidal cell layer ( J:129338 )

• mutants exhibit a modest split of the pyramidal layer in area CA1 and CA3

• however, do not show an obvious cerebral cortical layering defects

abnormal neocortex morphology ( J:100552 )

• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells

cellular

increased neuron apoptosis ( J:100552 )

• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone

abnormal neuronal migration ( J:100552 )

• migration defects in the hippocampus are seen