Phenotypes Associated with This Genotype

Genotype
MGI:3589667

• Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk
• Genetic Background: B6.129S7-Fst^tm1Zuk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:81451 )

• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons

abnormal olfactory sensory neuron morphology ( J:81451 )

• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium

decreased neuronal precursor cell number ( J:81451 )

taste/olfaction

abnormal olfactory epithelium morphology ( J:81451 )

• homozygotes display a 38% decrease in thickness of the olfactory epithelium

abnormal olfactory sensory neuron morphology ( J:81451 )

• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium

vision/eye

thin retina ganglion layer ( J:99244 )

• mutant retinas exhibit a 26% reduction in the number of cells in the ganglion cell layer and a marked decrease in thickness of the differentiated ganglion cell layer

• unlike the situation in olfactory epithelium, mutant retinas display normal overall thickness as well as normal progenitor cell proliferation

• in addition, mutant retinas show no obvious differences in amacrine cell or photoreceptor production relative to wild-type

respiratory system

abnormal olfactory epithelium morphology ( J:81451 )

• homozygotes display a 38% decrease in thickness of the olfactory epithelium

abnormal olfactory sensory neuron morphology ( J:81451 )

• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium

craniofacial

abnormal olfactory epithelium morphology ( J:81451 )

• homozygotes display a 38% decrease in thickness of the olfactory epithelium

abnormal olfactory sensory neuron morphology ( J:81451 )

• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium

cellular

abnormal neuron differentiation ( J:81451 )

• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons

growth/size/body

abnormal olfactory epithelium morphology ( J:81451 )

• homozygotes display a 38% decrease in thickness of the olfactory epithelium

abnormal olfactory sensory neuron morphology ( J:81451 )

• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium