Phenotypes Associated with This Genotype

Genotype
MGI:3589555

• Allelic Composition: Psen1^tm1Tak/Psen1^tm1Tak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:99353 )

• during place learning in a Morris water maze homozygotes have increased quadrant entries and escape latencies compared to wild-type mice; however motor coordination and swimming ability are not impaired and performance in the probe trial is normal

increased startle reflex ( J:99353 )

• homozygotes are more likely than wild-type mice to display whole-body startle following an auditory stimulus

increased grip strength ( J:99353 )

• homozygotes display a tighter grip response on a horizontal grid

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:99353