Phenotypes Associated with This Genotype

Genotype
MGI:3588990

• Allelic Composition: Mgp^tm1Kry/Mgp^tm1Kry; Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: involves: Black Swiss * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79746 )

• on average, double homozygotes die significantly earlier (4.4 0.2 weeks) than single Mgp^tm1Kry homozygotes (6.6 1.0 weeks) as a result of increased vascular calcification

• accelerated vascular calcification correlates with accelerated vascular rupture, subsequent hemorrhage and increaed mortality

cardiovascular system

abnormal aorta morphology ( J:79746 )

calcified artery ( J:79746 )

• relative to single Mgp^tm1Kry homozygotes, double homozygotes exhibit an accelerated and enhanced medial calcification of their aortae, with a ~2-fold and a >3-fold increase in calcification noted at 2 weeks and 4 weeks, respectively

• calcification initiates in the arterial media in association with elastic lamina, and progresses to fully mineralized media, mild to moderate intimal and medial thickening, fragmentation of elastic laminae, and arterial wall rupture

aneurysm ( J:79746 )

• arterial calcification ultimately results in aneurysm formation in calcified vessels

internal hemorrhage ( J:79746 )

• similar to Mgp^tm1Kry single homozygotes, double homozygotes exhibit vascular rupture and subsequent hemorrhage as a result of severe vascular calcification