Phenotypes for Apoe Tlr4 MGI:3588777 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Tlr4^tm1Aki/Tlr4^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (146 available)
Tlr4^tm1Aki mutation (7 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal susceptibility to atherosclerosis ( J:91481 )

• 24% reduction in atherosclerotic lesions relative to mice homozygous only for Apoe^tm1Unc

• reduced lipid content of aortic sinus plaques

• reduced infiltration of plaques by macrophage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23