Mouse Genome Informatics
cx
    Apoetm1Unc/Apoetm1Unc
Tlr4tm1Aki/Tlr4tm1Aki

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• 24% reduction in atherosclerotic lesions relative to mice homozygous only for Apoetm1Unc
• reduced lipid content of aortic sinus plaques
• reduced infiltration of plaques by macrophage

Mouse Models of Human Disease
OMIM IDRef(s)
Toll-Like Receptor 4; TLR4 603030 J:91481