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Phenotypes Associated with This Genotype
Genotype
MGI:3588777
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Tlr4tm1Aki mutation (5 available); any Tlr4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 24% reduction in atherosclerotic lesions relative to mice homozygous only for Apoetm1Unc (J:91481)
• reduced lipid content of aortic sinus plaques (J:91481)
• reduced infiltration of plaques by macrophage (J:91481)
• 24% reduction in atherosclerotic lesions relative to mice homozygous only for Apoetm1Unc (J:91481)
• reduced lipid content of aortic sinus plaques (J:91481)
• reduced infiltration of plaques by macrophage (J:91481)

Mouse Models of Human Disease
OMIM ID Ref(s)
Toll-Like Receptor 4; TLR4 603030 J:91481


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory