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Phenotypes Associated with This Genotype
Genotype
MGI:3588776
Allelic
Composition
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4tm1Aki mutation (5 available); any Tlr4 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased neutrophil chemotaxis
• weights of mesenteric lymph nodes 2X controls
• colitis induced by dextran sodium sulfate involves less inflammatory cell infiltration with fewer neurophils in the lamina propria and submucosa
• epithelial damage normal but decreased epithelial proliferation
• earlier and more severe rectal bleeding
• increased numbers of gram (-) bacteria in mesenteric lymph node

hematopoietic system
• decreased neutrophil chemotaxis
• reduced hemoglobin in mice with colitis induced by dextran sodium sulfate

cellular
• decreased neutrophil chemotaxis

Mouse Models of Human Disease
OMIM ID Ref(s)
Toll-Like Receptor 4; TLR4 603030 J:98224


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory