Mouse Genome Informatics
hm
    Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• decreased neutrophil chemotaxis
• weights of mesenteric lymph nodes 2X controls
• colitis induced by dextran sodium sulfate involves less inflammatory cell infiltration with fewer neurophils in the lamina propria and submucosa
• epithelial damage normal but decreased epithelial proliferation
• earlier and more severe rectal bleeding
• increased numbers of gram (-) bacteria in mesenteric lymph node

hematopoietic system
• decreased neutrophil chemotaxis
• reduced hemoglobin in mice with colitis induced by dextran sodium sulfate

cellular
• decreased neutrophil chemotaxis

Mouse Models of Human Disease
OMIM IDRef(s)
Toll-Like Receptor 4; TLR4 603030 J:98224