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Phenotypes Associated with This Genotype
Genotype
MGI:3588776
Allelic
Composition
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4tm1Aki mutation (5 available); any Tlr4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased neutrophil chemotaxis (J:98224)
• decreased neutrophil chemotaxis (J:98224)
• weights of mesenteric lymph nodes 2X controls (J:98224)
• weights of mesenteric lymph nodes 2X controls (J:98224)
• colitis induced by dextran sodium sulfate involves less inflammatory cell infiltration with fewer neurophils in the lamina propria and submucosa (J:98224)
• epithelial damage normal but decreased epithelial proliferation (J:98224)
• earlier and more severe rectal bleeding (J:98224)
• colitis induced by dextran sodium sulfate involves less inflammatory cell infiltration with fewer neurophils in the lamina propria and submucosa (J:98224)
• epithelial damage normal but decreased epithelial proliferation (J:98224)
• earlier and more severe rectal bleeding (J:98224)
• increased numbers of gram (-) bacteria in mesenteric lymph node (J:98224)
• increased numbers of gram (-) bacteria in mesenteric lymph node (J:98224)

hematopoietic system
• decreased neutrophil chemotaxis (J:98224)
• decreased neutrophil chemotaxis (J:98224)
• reduced hemoglobin in mice with colitis induced by dextran sodium sulfate (J:98224)
• reduced hemoglobin in mice with colitis induced by dextran sodium sulfate (J:98224)

cellular
• decreased neutrophil chemotaxis (J:98224)
• decreased neutrophil chemotaxis (J:98224)

Mouse Models of Human Disease
OMIM ID Ref(s)
Toll-Like Receptor 4; TLR4 603030 J:98224


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory