About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3588775
Allelic
Composition
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4tm1Aki mutation (5 available); any Tlr4 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine
• reduced responsiveness to endotoxin (LPS)
• following exposure to inactivated H5N1 virus, acute-lung injury and IL6 production are attenuated compared to in wild-type mice

homeostasis/metabolism
• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine
• following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance, edema, and serum IL6 levels
• following exposure to 1-palmitoyl-2-arachidonoyl-phosphatidylcholine, lung function is improved and IL6 production is decreased compared to in similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory