Mouse Genome Informatics
hm
    Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine
• following exposure to inactivated H5N1 virus, acute-lung injury and IL6 production are attenuated compared to in wild-type mice
• reduced responsiveness to endotoxin (LPS)

homeostasis/metabolism
• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine
• following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance, edema, and serum IL6 levels
• following exposure to 1-palmitoyl-2-arachidonoyl-phosphatidylcholine, lung function is improved and IL6 production is decreased compared to in similarly treated wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Toll-Like Receptor 4; TLR4 603030 J:53519