Phenotypes Associated with This Genotype

Genotype
MGI:3588775

• Allelic Composition: Tlr4^tm1Aki/Tlr4^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating interleukin-6 level ( J:145306 )

• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine

increased susceptibility to bacterial infection ( J:53519 )

• reduced responsiveness to endotoxin (LPS)

decreased susceptibility to Orthomyxoviridae infection ( J:145306 )

• following exposure to inactivated H5N1 virus , acute-lung injury and IL6 production are attenuated compared to in wild-type mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:145306 )

• following exposure to acid-induced acute lung injury, LPS, or 1-palmitoyl-2-arachidonoyl-phosphatidylcholine

decreased susceptibility to injury ( J:145306 )

• following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance, edema, and serum IL6 levels

• following exposure to 1-palmitoyl-2-arachidonoyl-phosphatidylcholine, lung function is improved and IL6 production is decreased compared to in similarly treated wild-type mice