Phenotypes Associated with This Genotype

Genotype
MGI:3588574

• Allelic Composition: Gdnf^tm1Rosl/Gdnf⁺; Nrtn^tm1Jmi/Nrtn^tm1Jmi
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system

abnormal enteric neuron morphology ( J:82456 )

• decrease in the number and cell size of small bowel and colon myenteric and submucosal neurons

• density of acetylcholinesterase-stained neuronal fibers in the myenteric plexus is reduced to a similar extent as in homozygous Nrtn^tm1Jmi mice

abnormal neurotransmitter secretion ( J:82456 )

• 70-95% reduction in substance P and VIP release

muscle

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation