Phenotypes Associated with This Genotype

Genotype
MGI:3588501

• Allelic Composition: Gdnf^tm1Rosl/Gdnf^tm1Rosl
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:33808 )

• die 1-1.5 days after birth

renal/urinary system

abnormal metanephric mesenchyme morphology ( J:33808 )

• do not have a properly developed metanephric blastema at E11.5

absent kidney ( J:33808 )

• 16 of 20 have complete bilateral renal agenesis

absent ureter ( J:33808 )

• 16 of 20 have complete uretal agenesis

absent ureteric bud ( J:33808 )

• absent ureteric bud

nervous system

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

absent enteric neurons ( J:33808 )

• vagal neural crest-derived neurons are absent in small and large intestine and only a few are detected in the stomach

abnormal innervation pattern to muscle ( J:110955 )

• peroneal nerve is reduced in diameter while tibial nerve diameter is increased in diameter; mutant phenotype is more severe than that of Ret^tm1Kln; Tg(Pgk1-cre)1Lni or Ret^tm1Kln;Tg(Nes-cre)1Kln mice

abnormal motor neuron innervation pattern ( J:132854 )

• posterior Psoas major lacks innervation

decreased motor neuron number ( J:132854 )

• loss of more than 20% of motor neurons at the lumbar level

• elevated apoptosis of motor neurons between 13.5 and E15.5

abnormal cranial ganglia morphology ( J:33808 )

• 40% reduction in the number of neurons and smaller size of neurons in petrosal-nodose ganglia of P0 mice, however no differences in hindbrain noradrenergic or midbrain dopaminergic neurons

small dorsal root ganglion ( J:33808 )

• 23% reduction in the number of neurons and smaller size of neurons in dorsal root ganglia of P0 mice

• however, no differences in trigeminal sensory and vestibular ganglia are seen

digestive/alimentary system

abnormal intestine morphology ( J:33808 )

• thinner smooth muscle in the intestinal wall

hematopoietic system

abnormal spleen red pulp morphology ( J:33808 )

• exhibit mild multifocal necrosis in the red pulp at sites of active hematopoiesis

immune system

abnormal spleen red pulp morphology ( J:33808 )

• exhibit mild multifocal necrosis in the red pulp at sites of active hematopoiesis

reproductive system

abnormal ovary topology ( J:33808 )

♀ • reversal in the orientation of the ovary in relation to the abdominal viscera

endocrine/exocrine glands

abnormal ovary topology ( J:33808 )

♀ • reversal in the orientation of the ovary in relation to the abdominal viscera

muscle

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris