Mouse Genome Informatics
hm
    Ifngtm1Ts/Ifngtm1Ts
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
N
• mice are able to clear infections of Pneumocystis carinii, similar to controls (J:119206)
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
• macrophages from BCG infected mice exhibit reduced class II expression
• exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction
• however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls
• increased mortality following a sublethal dose of Mycobacterium bovis (BCG )
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice
• however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice
• reduced surival of cardiac grafts relative to controls

tumorigenesis
• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice
• tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls

craniofacial
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

skeleton
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

hematopoietic system
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
• macrophages from BCG infected mice exhibit reduced class II expression

integument
• following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls
• however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls

cellular
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

mortality/aging
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Malaria, Susceptibility to 611162 J:189794