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Phenotypes Associated with This Genotype
Genotype
MGI:3587743
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice are able to clear infections of Pneumocystis carinii, similar to controls
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
• macrophages from BCG infected mice exhibit reduced class II expression
• exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction
• however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls
• increased mortality following a sublethal dose of Mycobacterium bovis (BCG )
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice
• however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice
• reduced surival of cardiac grafts relative to controls

tumorigenesis
• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice
• tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls

craniofacial
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

skeleton
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

hematopoietic system
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
• macrophages from BCG infected mice exhibit reduced class II expression

integument
• following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls
• however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls

cellular
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

mortality/aging
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Malaria, Susceptibility to 611162 J:189794


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory