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Phenotypes Associated with This Genotype
Genotype
MGI:3586704
Allelic
Composition
Fzd9tm1Sjp/Fzd9tm1Sjp
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd9tm1Sjp mutation (0 available); any Fzd9 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 10 months of age, latency of seizure onset is about half that of wild-type or heterozygous mice; however spontaneous seizures are not seen
• at E14.5 there is a slight but significant increase in M-phase precursor cells in the medial cortical wall and at E18.5 there is a significant increase in M-phase precursor cells in the dentate gyrus; however by P8 no difference is seen
• at E14.5 a more than 5-fold increased in the number of apoptotic cell clusters and the number of cells per cluster is detected in the dentate anlage and later in gestation, about a 3-fold increase in the number of apoptotic cells in the dentate and fimbria is detected by TUNEL staining
• a 20% decrease in the number of dentate granule cells is seen at 12 weeks of age; however no change in the number of pyramidal cells is detected
• a dramatic increase in the mossy cell number and a substantial increase in neuronal density are seen in the hilus

behavior/neurological
• at 10 months of age, latency of seizure onset is about half that of wild-type or heterozygous mice; however spontaneous seizures are not seen
• visually mediated, spatial memory is impaired

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:99893


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory