Phenotypes Associated with This Genotype

Genotype
MGI:3586343

• Allelic Composition: Csf2^tm1Dran/Csf2^tm1Dran; Il3^tm1Glli/Il3^tm1Glli
• Genetic Background: C.129S2-Csf2^tm1Dran Il3^tm1Glli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )

• dramatically reduced response to secondary challenge in tests for contact hypersensitivity

• very reduced cellular infiltrates

• much reduced edema

• very little keratinocyte activation

lung inflammation ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

• extensive lymphoid hyperplasia around both airways and veins

respiratory system

lung inflammation ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

• extensive lymphoid hyperplasia around both airways and veins

abnormal surfactant secretion ( J:67404 )

• accumulation of surfactant in intra-alveolar spaces

hematopoietic system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow