Phenotypes Associated with This Genotype

Genotype
MGI:3584536

• Allelic Composition: Ptk2b^tm1Schl/Ptk2b^tm1Schl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:99741 )

• homozygous macrophages do not show an obvious increase in Ca²⁺ concentration after chemokine stimulation unlike wild-type macrophages

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice

decreased acute inflammation ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced with only 2.8 x 10⁶ cells per injected area compared to 4.8 x 10⁶ cells per injected area in wild-type mice

cellular

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:99741 )

• homozygous macrophages do not show an obvious increase in Ca²⁺ concentration after chemokine stimulation unlike wild-type macrophages

impaired macrophage chemotaxis ( J:99741 )

• inflammation in response to subcutaneous carrageenan stimulation is reduced and only 20% of the cells in the infiltrate are macrophages compared to 70% in wild-type mice