Ptk2b^tm1Schl
Targeted Allele Detail

Summary

• Symbol: Ptk2b^tm1Schl
• Name: PTK2 protein tyrosine kinase 2 beta; targeted mutation 1, Joseph Schlessinger
• MGI ID: MGI:3583796
• Synonyms: Pyk2^-, PYK2 KO
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^tm1Schl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99741
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the 5' portion of the sequence encoding the protein tyrosine kinase domain. Northern and western blot analyses indicate this is a null allele. (J:99741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 55 strains or lines available

References

• Original: J:99741 Okigaki M, et al., Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10740-5
• All: 23 reference(s)