Phenotypes Associated with This Genotype

Genotype
MGI:3584507

• Allelic Composition: Foxp2^tm1Bux/Foxp2⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological analysis of brains of Foxp2^tm1Bux and wild type mice

behavior/neurological

decreased vocalization ( J:99864 )

• at 6 days of age the incidence of vocalization over time is reduced and at 10 days of age a profound decrease in ultrasonic vocalizations is observed; however the duration, peak frequency, and bandwidth of the vocalizations are normal

nervous system

abnormal radial glial cell morphology ( J:99864 )

• radial glial fibers appear less well aligned and thinner

abnormal cerebellum external granule cell layer morphology ( J:99864 )

• a 1 cell thick external granule cell layer is seen at 15 - 17 days of age; however adult heterozygotes lack an external granule cell layer similar to wild-type mice

growth/size/body

postnatal growth retardation ( J:99864 )

cellular

abnormal radial glial cell morphology ( J:99864 )

• radial glial fibers appear less well aligned and thinner