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Phenotypes Associated with This Genotype
Genotype
MGI:3584473
Allelic
Composition
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span is 15.4 months (J:95316)
• mean life span is 15.4 months (J:95316)

tumorigenesis
• 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes (J:95316)
• 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes (J:95316)
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)
• 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma (J:95316)
• 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma (J:95316)
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)

cellular
• in response to irradiation (J:158953)
• in response to irradiation (J:158953)
• a larger fraction of MEFs are in S phase compared to wild-type mice (J:95316)
• a larger fraction of MEFs are in S phase compared to wild-type mice (J:95316)

hematopoietic system
• hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice (J:158953)
• however, no competitive advantage is observed over similarly treated Cdkn2atm2.1Rdp cells in irradiation chimera experiments (J:158953)
• hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice (J:158953)
• however, no competitive advantage is observed over similarly treated Cdkn2atm2.1Rdp cells in irradiation chimera experiments (J:158953)
• in response to irradiation (J:158953)
• in response to irradiation (J:158953)

immune system
• in response to irradiation (J:158953)
• in response to irradiation (J:158953)

homeostasis/metabolism
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors (J:170769)

endocrine/exocrine glands
• in response to irradiation (J:158953)
• in response to irradiation (J:158953)

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory