Mouse Genome Informatics
ht
    Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mean life span is 15.4 months

tumorigenesis
• 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors
• 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

cellular
• in response to irradiation
• a larger fraction of MEFs are in S phase compared to wild-type mice

hematopoietic system
• hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice
• however, no competitive advantage is observed over similarly treated Cdkn2atm2.1Rdp cells in irradiation chimera experiments
• in response to irradiation

immune system
• in response to irradiation

homeostasis/metabolism
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

endocrine/exocrine glands
• in response to irradiation

Mouse Models of Human Disease
OMIM IDRef(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316