Phenotypes Associated with This Genotype

Genotype
MGI:3584473

• Allelic Composition: Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urinary system tumor incidence ( J:170769 )

• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

mortality/aging

premature death ( J:95316 )

• mean life span is 15.4 months

neoplasm

increased tumor incidence ( J:95316 )

• 19% have multiple tumors compared to 44% of Trp53^tm3.1Tyj heterozygotes

increased incidence of tumors by chemical induction ( J:170769 )

• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

increased carcinoma incidence ( J:95316 )

• 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma

increased urinary system tumor incidence ( J:170769 )

• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

cellular

decreased cellular sensitivity to gamma-irradiation ( J:259337 )

• in thymocytes exposed to gamma radiation

decreased thymocyte apoptosis ( J:158953 )

• in response to irradiation

increased fibroblast proliferation ( J:95316 )

• a larger fraction of MEFs are in S phase compared to wild-type mice

hematopoietic system

abnormal hematopoietic system physiology ( J:158953 )

• hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice

• however, no competitive advantage is observed over similarly treated Cdkn2a^tm2.1Rdp cells in irradiation chimera experiments

decreased thymocyte apoptosis ( J:158953 )

• in response to irradiation

immune system

decreased thymocyte apoptosis ( J:158953 )

• in response to irradiation

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:170769 )

• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:158953 )

• in response to irradiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316