Mouse Genome Informatics
ht
    Trp53tm1Tyj/Trp53tm2.1Tyj
involves: 129S2/SvPas * 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mean life span is 4.5 months
• a slight decrease is seen in the number of females born

tumorigenesis
• 57% have multiple tumors, significantly more than in Trp53tm1Tyj homozygotes (32%)
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (50% compared to 66%)
• carcinomas are seen in 16% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas
• most carcinomas are derived from epithelial cells
• the incidence of hemangiosarcomas is increased to 62% compared to 32% in Trp53tm1Tyj homozygotes and these tumors are highly aggressive

Mouse Models of Human Disease
OMIM IDRef(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316