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Phenotypes Associated with This Genotype
Genotype
MGI:3584464
Allelic
Composition
Trp53tm1Tyj/Trp53tm2.1Tyj
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (142 available)
Trp53tm2.1Tyj mutation (2 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span is 4.5 months (J:95316)
• mean life span is 4.5 months (J:95316)
• a slight decrease is seen in the number of females born (J:95316)
• a slight decrease is seen in the number of females born (J:95316)

tumorigenesis
• 57% have multiple tumors, significantly more than in Trp53tm1Tyj homozygotes (32%) (J:95316)
• 57% have multiple tumors, significantly more than in Trp53tm1Tyj homozygotes (32%) (J:95316)
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (50% compared to 66%) (J:95316)
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (50% compared to 66%) (J:95316)
• carcinomas are seen in 16% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas (J:95316)
• most carcinomas are derived from epithelial cells (J:95316)
• carcinomas are seen in 16% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas (J:95316)
• most carcinomas are derived from epithelial cells (J:95316)
• the incidence of hemangiosarcomas is increased to 62% compared to 32% in Trp53tm1Tyj homozygotes and these tumors are highly aggressive (J:95316)
• the incidence of hemangiosarcomas is increased to 62% compared to 32% in Trp53tm1Tyj homozygotes and these tumors are highly aggressive (J:95316)

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory