Mouse Genome Informatics
cx
    Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja

involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Growth retardation of Ins1tm1Jja/Ins1tm1Jja Ins2tm1Jja/Ins2tm1Jja mice

mortality/aging
• death in 48 hours after birth on average

endocrine/exocrine glands
• significant hyperplasia
• about 1.5X larger than in littermate controls

homeostasis/metabolism
• severely diabetic (J:77595)
• glycosuria detectable after pups suckle
• ketoacidosis

growth/size/body
• mean body weight within a few hours of birth 22% less than littermate controls

liver/biliary system

renal/urinary system
• glycosuria detectable after pups suckle

embryogenesis

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young; MODY 606391 J:40377 , J:77595