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Phenotypes Associated with This Genotype
Genotype
MGI:3584436
Allelic
Composition
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (4 available); any Ins1 mutation (32 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Growth retardation of Ins1tm1Jja/Ins1tm1Jja Ins2tm1Jja/Ins2tm1Jja mice

mortality/aging
• death in 48 hours after birth on average

endocrine/exocrine glands
• significant hyperplasia
• about 1.5X larger than in littermate controls

homeostasis/metabolism
• severely diabetic (J:77595)
• glycosuria detectable after pups suckle
• ketoacidosis

growth/size/body
• mean body weight within a few hours of birth 22% less than littermate controls

liver/biliary system

renal/urinary system
• glycosuria detectable after pups suckle

embryo

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young; MODY 606391 J:40377 , J:77595


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory