Analysis Tools
behavior/neurological
limb grasping
(
J:99291
)
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• at 1 month of age 78% of mutants clutch compared to 8% of wild-type mice and by 6 months all mutants clutch compared to 16% of wild-type
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• at 4 - 5 weeks of age performance on the rotarod test is impaired
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nervous system
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• tyrosine hydroxylase-positive neurons are reduced by about 27% and 23% at postnatal day 0 and 120, respectively and appear disorganized
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• the extent of the substantia nigra pars compacta appears reduced in coronal sections but the density of calbindin-positive neurons appears increased
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