Analysis Tools
homeostasis/metabolism
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• doubly transgenic mice begin to exhibit glucosuria as early as 20 days of age; by 70 days, all the mice have urine glucose concentrations greater than 15 mM
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renal/urinary system
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• doubly transgenic mice begin to exhibit glucosuria as early as 20 days of age; by 70 days, all the mice have urine glucose concentrations greater than 15 mM
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immune system
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• histological examination of 5 doubly transgenic mice aged 5-68 days revealed heavy lymphocyte infiltration of the pancreatic islets of all mice; 82% of islets, on average, were infiltrated
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endocrine/exocrine glands
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• severe depletion of beta cells in infiltrated islets of the five mice examined
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