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Phenotypes Associated with This Genotype
Genotype
MGI:3582785
Allelic
Composition		 Bcl6tm2Rdf/Bcl6tm2Rdf
Ighmtm1(Bcl6)Rdf/?
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm2Rdf mutation (0 available); any Bcl6 mutation (57 available)
Ighmtm1(Bcl6)Rdf mutation (1 available); any Ighm mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:98937 )
• Igh-6tm1(Bcl6)Rdf was unable to rescue the inflammatory phenotype observed in homozygous Bcl6 null mice
abnormal spleen germinal center morphology ( J:98937 )
• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures

hematopoietic system
abnormal spleen germinal center morphology ( J:98937 )
• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory