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Phenotypes Associated with This Genotype
Genotype
MGI:3582615
Allelic
Composition
Mkkstm1Vcs/Mkkstm1Vcs
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mkkstm1Vcs mutation (1 available); any Mkks mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the proportion of homozygotes is decreased to 19.1% and data suggest death late in gestation (J:99276)
• the proportion of homozygotes is decreased to 19.1% and data suggest death late in gestation (J:99276)

vision/eye
• at 2-3 months of age a slight reduction in the outer nuclear layer and some cell nuclei in the subretinal space were seen (J:99276)
• at 8 months of age the outer nuclear layer is completely degenerated and no remnants of the inner or outer segments are seen (J:99276)
• at 2-3 months of age a slight reduction in the outer nuclear layer and some cell nuclei in the subretinal space were seen (J:99276)
• at 8 months of age the outer nuclear layer is completely degenerated and no remnants of the inner or outer segments are seen (J:99276)

growth/size/body
• at weaning homozygotes weigh significantly less than wild-type or heterozygous littermates (J:99276)
• at weaning homozygotes weigh significantly less than wild-type or heterozygous littermates (J:99276)
• by 28 weeks of age homozygotes weigh significantly more than wild-type or heterozygous littermates and the weight difference is greater in females than in males (J:99276)
• by 28 weeks of age homozygotes weigh significantly more than wild-type or heterozygous littermates and the weight difference is greater in females than in males (J:99276)

cardiovascular system
• diastolic, systolic, and mean blood pressure are increased with mean arterial pressure increased on average by 12 mmHg (J:99276)
• diastolic, systolic, and mean blood pressure are increased with mean arterial pressure increased on average by 12 mmHg (J:99276)

behavior/neurological
• homozygotes are more docile during handling and in 72% and 76% of trials were submissive to wild-type and heterozygous mice, respectively (J:99276)
• homozygotes are more docile during handling and in 72% and 76% of trials were submissive to wild-type and heterozygous mice, respectively (J:99276)
• 24 hour telemetry indicates a significant decrease in activity; however, no significant differences in muscle or motor neuron function dependent behaviors are seen (J:99276)
• 24 hour telemetry indicates a significant decrease in activity; however, no significant differences in muscle or motor neuron function dependent behaviors are seen (J:99276)
• females are less vocal during handling (J:99276)
• females are less vocal during handling (J:99276)

homeostasis/metabolism

limbs/digits/tail
N
• no polydactyly or other notable limb malformations are seen (J:99276)
• no polydactyly or other notable limb malformations are seen (J:99276)

reproductive system
• spermatozoa lack flagella but have normally formed heads and cilia on epithelial cells form normally (J:99276)
• spermatozoa lack flagella but have normally formed heads and cilia on epithelial cells form normally (J:99276)
(J:99276)
(J:99276)

taste/olfaction
• decreased olfactory ability suggested by a decreased ability to find hidden food (J:99276)
• decreased olfactory ability suggested by a decreased ability to find hidden food (J:99276)

cellular
• spermatozoa lack flagella but have normally formed heads and cilia on epithelial cells form normally (J:99276)
• spermatozoa lack flagella but have normally formed heads and cilia on epithelial cells form normally (J:99276)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory