Phenotypes Associated with This Genotype

Genotype
MGI:3582202

• Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi; Apoe^tm1Unc/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cutaneous xanthomatosis and alopecia in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice

vision/eye

Meibomian gland atrophy ( J:63468 )

dry eyes ( J:63468 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:63468 )

• adrenocortical lipid depletion

increased circulating cholesterol level ( J:63468 )

• increased serum cholesterol levels

• hypercholesterolemia when fed a high fat diet

xanthoma ( J:63468 )

• cutaneous xanthomatosis

integument

alopecia ( J:63468 )

decreased hair follicle number ( J:63468 )

abnormal dermal layer morphology ( J:63468 )

• necrotic dermis

Meibomian gland atrophy ( J:63468 )

mixed cellular infiltration to dermis ( J:63468 )

• macrophage infiltration of dermis

thick dermal layer ( J:63468 )

skin lesions ( J:63468 )

abnormal skin condition ( J:63468 )

• rough skin

thick skin ( J:63468 )

endocrine/exocrine glands

Meibomian gland atrophy ( J:63468 )