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Phenotypes Associated with This Genotype
Genotype
MGI:3582060
Allelic
Composition
Gjc1tm1Weil/Gjc1tm1Weil
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Weil mutation (1 available); any Gjc1 mutation (17 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• cone bipolar cells are present in mutants but they are void of glycine, indicating that neurotransmitter coupling between ON bipolar cells and glycinergic AII amacrine cells is disrupted in mutants
• scotopic electroretinogram recordings in response to 20 msec white light flashes in dark-adapted mutants showed that b-wave amplitudes were smaller than in wild-type controls but a-waves did not differ, indicating a defect in the rod driven circuitry


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory