Phenotypes Associated with This Genotype

Genotype
MGI:3580499

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: B6.129S6(Cg)-Spp1^tm1Blh/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:99574 )

N • despite strong Spp1⁺ mRNA expression in wild-type testis cords and protein localization in the cytoplasm of Sertoli cells, testes from E13.5 homozygotes show no differences in the number or distribution of Sertoli, Leydig, or germ cells relative to wild-type testes

hematopoietic system

decreased hematocrit ( J:133795 )

• hematocrit levels in male mice are 10% to 12% lower than in wild-type mice

• however, hematocrit levels in female mice are normal

decreased hemoglobin content ( J:133795 )

• hemoglobin levels in male mice are 10% to 12% lower than in wild-type mice

• however, hemoglobin levels in female mice are normal

abnormal hematopoietic system physiology ( J:133795 )

• proliferation of cultured erythroblasts isolated from the bone marrow is less than proliferation of wild-type cells

• however, differentiation and apoptosis of erythroblasts are normal and addition of exogenous Spp1 restores erythroblast proliferation rates