Phenotypes Associated with This Genotype

Genotype
MGI:3580253

• Allelic Composition: Notch1^tm1Grid/Notch1^tm1Grid; Notch4^tm1Grid/Notch4^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta vasculature ( J:62571 )

• embryonic blood vessels fail to invade trophoblast

absent vitelline blood vessels ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

incomplete embryo turning ( J:62571 )

• did not complete embryonic turning

open neural tube ( J:62571 )

incomplete somite formation ( J:62571 )

• fewer somites formed

pale yolk sac ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

cardiovascular system

abnormal dorsal aorta morphology ( J:62571 )

• dorsal aortae lack lumens

abnormal intersomitic vessel morphology ( J:62571 )

• severely disorganized intersomitic vessels

abnormal placenta vasculature ( J:62571 )

• embryonic blood vessels fail to invade trophoblast

decreased angiogenesis ( J:62571 )

• vasculogenesis was normal but subsequent remodeling failed

absent vitelline blood vessels ( J:62571 )

• pale yolk sacs lacking obvious blood vessels

abnormal vein morphology ( J:62571 )

• lacking lumens

abnormal anterior cardinal vein morphology ( J:62571 )

• anterior cardinal veins discontinuous or missing

pericardial edema ( J:62571 )

nervous system

open neural tube ( J:62571 )

homeostasis/metabolism

pericardial edema ( J:62571 )