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Phenotypes Associated with This Genotype
Genotype
MGI:3579532
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Genetic
Background
B6.129S2-Mdktm1Tmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

behavior/neurological
N
• mice exhibit normal locomotor activity and acoustic startle reactivity
• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice

nervous system
• in the striatum
• adult mice exhibit reduced prepulse inhibition compared with wild-type mice
• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition

hearing/vestibular/ear
• mice experience low to moderate levels of auditory deficits

homeostasis/metabolism
• following partial hepatectomy (PH), amino-transferase levels are decreased
• in the striatum
• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%)
• omental adhesions reduced after peritoneal wall injury

liver/biliary system
• one day following partial hepatectomy (PH)

hematopoietic system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

cellular
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:151029


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory