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Phenotypes Associated with This Genotype
Genotype
MGI:3579100
Allelic
Composition		 H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type
male infertility ( J:98301 )
• produced no offspring when mated to wild-type females
impaired sperm penetration of zona pellucida ( J:98301 )
• impaired sperm penetration of zona pellucida from wild-type females

cellular
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory