Phenotypes Associated with This Genotype

Genotype
MGI:3578656

• Allelic Composition: Slc11a2^tm1Nca/Slc11a2^tm1Nca
• Genetic Background: 129S6.129S4-Slc11a2^tm1Nca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:98088 )

• by 7 days of age

• RBC transfusions prolong survival

hematopoietic system

microcytic anemia ( J:98088 )

abnormal erythrocyte morphology ( J:98088 )

decreased erythrocyte cell number ( J:98088 )

decreased hematocrit ( J:98088 )

decreased hemoglobin content ( J:98088 )

• by 3 days of age

decreased mean corpuscular hemoglobin concentration ( J:98088 )

• hypochromic erythrocytes

decreased mean corpuscular volume ( J:98088 )

anisocytosis ( J:98088 )

• diminished non-heme iron levels in liver, spleen, kidney, brain and heart

• liver iron levels elevated at birth

poikilocytosis ( J:98088 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:98088 )

N • total body iron levels relatively normal

growth/size/body

postnatal growth retardation ( J:98088 )

• progressive postnatal growth retardation

• weigh 30% less than controls by 3 days of age

integument

pallor ( J:98088 )

• at birth