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Phenotypes Associated with This Genotype
Genotype
MGI:3578414
Allelic
Composition
Fzd9tm1Uta/Fzd9tm1Uta
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd9tm1Uta mutation (1 available); any Fzd9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• exhibit moderately reduced lifespans

immune system
• exhibit accelerated atrophy with age
• reduction in CD43+B220+ pro/pre-B-cell populations
• decreased total B-cell number in the bone marrow despite relatively normal numbers of mature B cells in the periphery
• reduction in CD43+B220+ pro/pre-B-cell populations
• older homozygous null mice have a high frequency of peripheral blood leukocytosis
• older homozygous null mice exhibit eosinophilia
• older homozygous null mice exhibit mild neutrophilia
• older homozygous null mice exhibit monocytosis
• expansion of the red pulp with increased extramedullary hematopoiesis and deposition of increased amounts of hemosiderin
• spleens are approximately twice the normal size by 6 months of age
• although the white pulp is intact, there is some expansion of the marginal zones
• variably distorted nodal architecture
• an accumulation of plasma cells that filled and distended the medullary cords and were present in large patches in the paracortical zones
• lymph nodes are frequently enlarged, even at 3 months of age, with more than 50% of older homozygous null mice showing enlarged lymph nodes

hematopoietic system
• exhibit accelerated atrophy with age
• reduction in CD43+B220+ pro/pre-B-cell populations
• decreased total B-cell number in the bone marrow despite relatively normal numbers of mature B cells in the periphery
• reduction in CD43+B220+ pro/pre-B-cell populations
• older homozygous null mice have a high frequency of peripheral blood leukocytosis
• older homozygous null mice exhibit eosinophilia
• older homozygous null mice exhibit mild neutrophilia
• older homozygous null mice exhibit monocytosis
• expansion of the red pulp with increased extramedullary hematopoiesis and deposition of increased amounts of hemosiderin
• spleens are approximately twice the normal size by 6 months of age
• although the white pulp is intact, there is some expansion of the marginal zones

behavior/neurological
N
• do not exhibit any neurological, reflex or behavioral problems or hyperacusis

endocrine/exocrine glands
• exhibit accelerated atrophy with age

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Williams-Beuren Syndrome; WBS 194050 J:98133


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory