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Phenotypes Associated with This Genotype
Genotype
MGI:3577950
Allelic
Composition		 Adamts5tm1.1Eam/Adamts5tm1.1Eam
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Eam mutation (0 available); any Adamts5 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction

skeleton
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory